The liver is the primary organ responsible for the metabolism and elimination of foreign chemicals. Carbon tetrachloride (CCl4) can cause liver damage by converting into trichloromethyl radical [CCl3]- through the action of multiple cytochrome P450 isoforms. Subsequently, [CCl3]- undergoes a reaction with oxygen to produce the trichloromethyl peroxyl radical [CCl3OO]-, which induces hepatoprotective activity. The current study aimed to investigate the impact of kale, lupine, and their combination on the hepatotoxicity that CCl4 induces in male rats. Forty two male albino rats weighing (180± 5 g) were divided into seven groups: The first group (6 rats) was fed on basal diet and kept as a negative group. The other groups were treated by injection with 2 ml/kg of weight rat of CCL4 diluted with liquid paraffin (1:1 v: v) weekly during experiment period to induce hepatotoxicity. Group (2) was kept as a positive group . Groups (3&4) were given CCl4 with 5 and 10% lupine sprouts when Groups (5&6) were given CCl4 with 5 and 10% kale sprouts and the last group was given CCl4 with 10% mixture of both sprouts. Chemical composition and antioxidants activity were determined. Also, Body weight, feed intake, feed efficiency ratio, fasting blood glucose, insulin resistance, liver enzymes, kidney functions and oxidative stress parameters were estimated. Lupine had high protein, total flavonoids and ABTs %while kale had high in fat, fiber ,carbohydrates, total phenols and DPPH. The biochemical, MDA and CP data of positive control group showed elevated except HDL-c and other oxidative stress parameters. . The best results were recorded for the groups treated with CCl4 and were given10% of tested sprouts followed by 5%.lupine sprouts had high effect on the tested parameters followed by the mixture of both sprouts and the last was kale sprouts . So, it was concluded from the present results that administration of lupine, kale and its mixture can ameliorating CCl4 hepatotoxicity which might be due to their biologically active compounds and antioxidant.
G. EL-Nahas, Fathya, & M. El Gezery, Hoda. (2023). Effect of kale, lupine and its mixture sprouts on the biochemical parameters of hepatotoxicity rats with CCl4. المجلة العلمية لعلوم التربية النوعية, 18(18), 1957-1973. doi: 10.21608/sjsep.2023.386862
MLA
Fathya G. EL-Nahas; Hoda M. El Gezery. "Effect of kale, lupine and its mixture sprouts on the biochemical parameters of hepatotoxicity rats with CCl4", المجلة العلمية لعلوم التربية النوعية, 18, 18, 2023, 1957-1973. doi: 10.21608/sjsep.2023.386862
HARVARD
G. EL-Nahas, Fathya, M. El Gezery, Hoda. (2023). 'Effect of kale, lupine and its mixture sprouts on the biochemical parameters of hepatotoxicity rats with CCl4', المجلة العلمية لعلوم التربية النوعية, 18(18), pp. 1957-1973. doi: 10.21608/sjsep.2023.386862
VANCOUVER
G. EL-Nahas, Fathya, M. El Gezery, Hoda. Effect of kale, lupine and its mixture sprouts on the biochemical parameters of hepatotoxicity rats with CCl4. المجلة العلمية لعلوم التربية النوعية, 2023; 18(18): 1957-1973. doi: 10.21608/sjsep.2023.386862
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